274 papers
By mapping stem cell-based axial organoids to stage-matched human embryos, this study reveals that organoids contain neuromesodermal progenitors with a strong neural bias and identifies TGF-beta inhibition as a key regulator of the transition from anterior to posterior progenitors during human axial elongation.
This study constructs a comprehensive spatiotemporal transcriptomic atlas of the mouse placenta (STAMP) and reveals that glycogen trophoblast cells provide essential metabolic support through regulated glycogen breakdown, which is critical for maintaining fetal viability.
This study identifies the microtubule-binding protein EML3 as essential for mammalian embryonic growth and cerebral cortical development, demonstrating that its absence disrupts the pial basement membrane structure and causes neuronal over-migration, resulting in a cobblestone brain malformation phenotype in mice.
This study demonstrates that Hippo signaling differentially regulates distinct SOX9+ progenitor subpopulations and their transitional states to control lung size through bifurcation and specify cell fates for conducting airways and alveolar epithelium, providing a comprehensive developmental map of mammalian lung construction.
This paper proposes Distribution-Aware Federated Learning (DA-FL), a novel framework that combines client-specific minority-class amplification factors with class-weighted loss to effectively mitigate non-IID and class-imbalanced challenges in diabetes prediction, significantly outperforming conventional methods like FedAvg in accuracy and stability on the CDC BRFSS 2021 dataset.
This study demonstrates that the gray short-tailed opossum exhibits accelerated postnatal development and an ancestral r-selected life history strategy without a pouch, suggesting that these traits likely facilitated the survival of early marsupials through the K-Pg extinction rather than hindering them.
This study overcomes the challenge of identifying cis-regulatory elements in large genomes by combining bulk and single-nucleus ATAC-seq with a cost-effective, assembly-free comparative genomics approach in *Parhyale hawaiensis* to successfully map functional regulatory regions.
This study reveals that elevated temperatures fatally disrupt early Drosophila embryogenesis by weakening the interaction between cortical F-actin and astral microtubules during the syncytial blastoderm stage, leading to mitotic failures and blastoderm holes that can be rescued by modulating specific gene expressions.
Using live imaging and quantitative modeling in developing zebrafish, this study reveals significant heterogeneity between Sonic Hedgehog response dynamics and cell fate specification in single neural progenitors, highlighting the precision limits of morphogen interpretation in small, dynamic cell fields.
This study reveals that transcriptional feedback within the Wnt pathway generates unexpected mRNA asymmetries in *C. elegans* seam cells that precede and reinforce cell fate decisions, uncovering hidden molecular heterogeneity that challenges established models of protein-based Wnt signaling.
This study identifies a neural crest-derived tunnel microtract (TMT) as a critical organ for T cell progenitor homing in both zebrafish and mice, revealing that the Sox10-Cdc42 axis drives its precise morphogenesis through F-actin remodeling to ensure proper T cell development.
This study characterizes the genomic organization and expression of the bovine DUXC gene in early embryos, providing the first full-length mRNA sequence and demonstrating that DUXC is expressed at pre-embryonic genome activation (EGA) stages with a subsequent decline dependent on minor EGA, suggesting its potential role as a bovine EGA inducer.
This study utilizes high-resolution spatial transcriptomics to reveal that zebrafish heart regeneration relies on the organization of macrophages into discrete cardio-immune microniches, where a specific fibroblast-macrophage axis (il34-csf1ra-egr1) orchestrates pro-regenerative states, while its disruption shifts macrophages toward pro-fibrotic inflammation and impairs tissue repair.
This study reveals that enteric nervous system (ENS) lineage potential is not intrinsically regionalized along the anterior-posterior axis but is instead shaped by a uniform temporal maturation program that is secondarily fine-tuned by extrinsic, region-specific microenvironmental cues, particularly PTN/MDK-PTPRZ1 signaling.
This study elucidates that Desert Hedgehog (Dhh) drives stem Leydig cell differentiation in Nile tilapia via a specific Ptch2/Gli1/Sf1 signaling axis, where Dhh signaling through the Ptch2 receptor activates Gli1 to upregulate Sf1, thereby orchestrating the lineage commitment of stem cells into functional adult Leydig cells.
Using intravital multiphoton imaging, this study reveals that skin capillary endothelial cells maintain a spatiotemporally conserved network of Ca2+ activity regulated by Connexin 43-mediated communication, where the loss of Cx43 causes sustained signaling and vascular dysfunction that can be non-cell-autonomously rescued by inhibiting L-type Ca2+ channels.
This study demonstrates that physiologically relevant, modest variations in sperm miRNA abundance are sufficient to quantitatively program embryonic gene expression and developmental outcomes through direct targeting and subsequent regulatory cascades, thereby establishing a mechanism for the epigenetic inheritance of environmentally influenced phenotypes.
This study reveals that MEIOSIN possesses an evolutionarily conserved, STRA8-independent function essential for initiating meiotic entry across vertebrates, positioning STRA8 as a later-acting enhancer rather than the sole ancestral driver of this process.
This study establishes a spatial and temporal atlas of tubulin isotype expression during chick neural crest epithelial-to-mesenchymal transition, revealing a systematic reprogramming of cytoskeletal architecture that coordinates microtubule composition with cell state transitions.
This study presents the first genome-wide analysis of all ten *C. elegans* DMRT genes, revealing that six exhibit sexually dimorphic expression in novel tissues and that their loss causes diverse neuronal differentiation defects, while also highlighting roles for some family members beyond sexual differentiation.